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Wits Immunology Research Program (WIRP)

Addressing Immune-Related Health Challenges in Africa

The Wits Immunology Research Program (WIRP), hosted within the Division of Immunology,  aims to advance knowledge and understanding of the immunology of diseases.

Join Us in Advancing Immunology Research

Join the Wits Immunology Research Program in transforming healthcare across Africa. Your partnership and support will help us build local research capacity and develop the next generation of African immunologists.

For more information, please contact Dr Christina Thobakgale at christina.thobakgale@wits.ac.za

Key Objectives and Research focus:

Basic, Experimental and Translational Research We investigate infectious diseases, allergies, autoimmune disorders, and transplant immunology to uncover immune mechanisms. These insights drive innovations in diagnostics, vaccine development, and treatment approaches while identifying correlates of protection.
Strengthening Research Capacity We enhance local research capabilities by integrating new technologies and building strategic partnerships, ensuring WIRP remains at the forefront of immunology research in Africa.
Clinical Applications Our research translates into practical tools that improve diagnostics, vaccines, and treatment, bridging the gap between discovery and clinical care.
Informing Policy Through collaboration with decision-makers, we ensure our findings inform public health strategies and policies, improving access to care for underserved populations.
Collaborative Partnerships We build strong relationships with clinical and research partners, enabling access to valuable clinical materials and cohorts for impactful interdisciplinary research.
Infectious Diseases Research Spotlight

Within our Immunology Research Program, one of our key research areas is focused on Infectious Diseases.

The immune system is an intricate network of cells and molecules that serves as our body's first line of defence against devastating infectious diseases.

From HIV to tuberculosis, hepatitis to cytomegalovirus, these pathogens continue to pose significant challenges to global health, making the understanding of immune responses more crucial than ever.

By unravelling the immune system's response to infectious agents, we aim to pioneer new approaches to diagnosis, treatment, and, potentially, prevention of these challenging infections that continue to impact millions of lives worldwide.

Key Research Questions

Some key research questions focusing on HIV, TB, Hepatitis, and CMV include:

  • What are the cellular immune responses induced by different infections and how can they be used to monitor treatment response?
  • What are the mechanisms of T & B cells, natural killer cells, monocytes and dendritic cells in infectious disease control?
  • How does the individual genetic make-up influence disease outcome and what are the implications for vaccination?
  • What are the characteristic features of protective responses that vaccines should aim to induce?
  • What metabolic pathways are induced in different disease settings?
  • What is the profile of anti-inflammatory and proinflammatory markers during different states?
  • How do anti-inflammatory and proinflammatory markers regulate disease?
  • How does involvement in clinical trials and the discovery of medicine drive innovation?
  • How do we leverage clinical trials to discover correlates of protection?
  • What are the opportunities for translating research observations into clinical practice?
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