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Palliative Care was established for the first time At Chris Hani Baragwanath Academic Hospital through the Department of Internal Medicine under the leadership of Prof Ken Huddle. The team consisting of a consultant and three nurses provided consultant palliative Care services in the hospital. In 2003, the N¡¯Doro Project funded by DFID was initiated. The N¡¯Doro Project, based at the Chris Hani Baragwanath Hospital in Soweto, has been at the forefront of developing and piloting a model of palliative care, providing community outreach palliative care to HIV/AIDS and cancer patients in the Soweto area, and providing training and conducting original research. In 2008 the Gauteng Centre of Excellence for Palliative Care was established at Chris Hani Baragwanath Hospital and adopted by the Gauteng Department of Health.  The Wits Centre for Palliative Care was established in 2012, with a view to furthering academic excellence in palliative care. In 2013, the Centre started providing paediatric palliative Care services.

The Centre consists of a team of doctors, professional nurses, enrolled nurses, social workers, social auxiliary workers, drivers, administrators and volunteer spiritual counsellors.