HPRU Publications
2024
Govender, D., Moloko, L., Papathanasopoulos, M., Tumba, N., Owen, G., & Calvey, T. (2024). Ibogaine administration following repeated morphine administration upregulates myelination markers 2′, 3′-cyclic nucleotide 3′-phosphodiesterase (CNP) and myelin basic protein (MBP) mRNA and protein expression in the internal capsule of Sprague Dawley rats. Frontiers in Neuroscience, 18, 1378841.
2023
Breiman, R. F., Demetriou, G., Naidu, G., Papathanasopoulos, M. A., Ruff, P., & Madhi, S. A. (2023). Shifting the center of gravity for addressing the rising cancer disease burden in Africa: A rationale for African-based integrative infectious diseases and oncology research. PLOS Global Public Health, 3(5), e0001970.
2022
Tumba, N. L., Owen, G. R., Killick, M. A., & Papathanasopoulos, M. A. (2022). Immunization with HIV-1 trimeric SOSIP. 664 BG505 or founder virus C (FVCEnv) covalently complexed to two-domain CD4S60C elicits cross-clade neutralizing antibodies in New Zealand white rabbits. Vaccine: X, 12, 100222.
Tumba, N. L., Naicker, P., Stoychev, S., Killick, M. A., Owen, G. R., & Papathanasopoulos, M. A. (2022). Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP. 664 trimer modulates its structural dynamics. Biochemical and Biophysical Research Communications, 612, 181-187.
Moshoette, T., Papathanasopoulos, M. A., & Killick, M. A. (2022). HIV-1 bispecific antibody iMab-N6 exhibits enhanced breadth but not potency over its parental antibodies iMab and N6. Virology Journal, 19(1), 143.
2020
Connell, B. J., Hermans, L. E., Wensing, A. M., Schellens, I., Schipper, P. J., van Ham, P. M., ... & Nijhuis, M. (2020). Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection. Scientific reports, 10(1), 15866.
2019
Moshoette, T., Ali, S. A., Papathanasopoulos, M. A., & Killick, M. A. (2019). Engineering and characterising a novel, highly potent bispecific antibody iMab-CAP256 that targets HIV-1. Retrovirology, 16, 1-12.
2018
Owen, G. R., Le, D., Stoychev, S., Cerutti, N. M., & Papathanasopoulos, M. (2018). Redox exchange of the disulfides of human two-domain CD4 regulates the conformational dynamics of each domain, providing insight into its mechanisms of control. Biochemical and biophysical research communications, 497(2), 811-817.
Achilonu, I., Elebo, N., Hlabano, B., Owen, G. R., Papathanasopoulos, M., & Dirr, H. W. (2018). An update on the biophysical character of the human eukaryotic elongation factor 1 beta: Perspectives from interaction with elongation factor 1 gamma. Journal of Molecular Recognition, 31(7), e2708.
Palumbo, P. J., Fogel, J. M., Hudelson, S. E., Wilson, E. A., Hart, S., Hovind, L., ... & Saravanan, S. (2018). Hiv drug resistance in adults receiving early vs. delayed antiretroviral therapy: HPTN 052. JAIDS Journal of Acquired Immune Deficiency Syndromes, 77(5), 484-491.
Abrahams, S., Mosebi, S., Fish, M. Q., Papathanasopoulos, M. A., & Hewer, R. (2018). Screening of the NIH Clinical Collection for inhibitors of HIV-1 integrase activity. South African Journal of Science, 114(3-4), 1-5.
2016
Steegen, K., Bronze, M., Papathanasopoulos, M. A., van Zyl, G., Goedhals, D., Variava, E., ... & Carmona, S. (2016). HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa. Journal of Antimicrobial Chemotherapy, 72(1), 210-219.
Steegen, K., Bronze, M., Papathanasopoulos, M. A., Van Zyl, G., Goedhals, D., Van Vuuren, C., ... & Carmona, S. C. (2016). Prevalence of Antiretroviral Drug Resistance in Patients Who Are Not Responding to Protease Inhibitor–Based Treatment: Results From the First National Survey in South Africa. The Journal of infectious diseases, 214(12), 1826-1830.
Steegen, K., Carmona, S., Bronze, M., Papathanasopoulos, M. A., Van Zyl, G., Goedhals, D., ... & Stevens, W. S. (2016). Moderate levels of pre-treatment HIV-1 antiretroviral drug resistance detected in the first South African national survey. PloS one, 11(12), e0166305.
Chikaonda, T., Ketseoglou, I., Nguluwe, N., Krysiak, R., Thengolose, I., Nyakwawa, F., ... & Papathanasopoulos, M. A. (2017). Molecular characterisation of rifampicin-resistant Mycobacterium tuberculosis strains from Malawi. African journal of laboratory medicine, 6(2), 1-7.
Moolla, N., Killick, M., Papathanasopoulos, M., & Capovilla, A. (2016). Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entry. Biochimica et Biophysica Acta (BBA)-General Subjects.
Owen, G. R., Channell, J. A., Forsyth, T. V., Haertlein, M., Mitchell, E. P., Capovilla, A. & Cerutti, N. M. (2016). Human CD4 metastability is a function of the allosteric disulfide bond in domain 2. Biochemistry.
2015
Killick, M. A., Grant, M. L., Cerutti, N. M., Capovilla, A., & Papathanasopoulos, M. A. (2015). Env–2dCD4 S60C complexes act as super immunogens and elicit potent, broadly neutralizing antibodies against clinically relevant human immunodeficiency virus type 1 (HIV-1). Vaccine,33(46), 6298-6306.
Tandon, V., Yadav, P., Sur, S., Abbat, S., Tiwari, V., Hewer, R. & Kukreti, S. (2015). Design, Synthesis, and Biological Evaluation of 1, 2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors. ACS medicinal chemistry letters, 6(10), 1065-1070.
Le Noury, D. A., Mosebi, S., Papathanasopoulos, M. A., & Hewer, R. (2015). Functional roles of HIV-1 Vpu and CD74: Details and implications of the Vpu–CD74 interaction. Cellular immunology, 298(1), 25-32.
Hoehn, K. B., Gall, A., Bashford-Rogers, R., Fidler, S. J., Kaye, S., Weber, J. N. & SPARTAC Trial Investigators. (2015). Dynamics of immunoglobulin sequence diversity in HIV-1 infected individuals. Phil. Trans. R. Soc. B,370(1676), 20140241.
Hamlyn, E., Stöhr, W., Cooper, D. A., Fisher, M., Tambussi, G., Schechter, M. & Mcclure, M. (2015). The effect of short-course antiretroviral therapy initiated in primary HIV-1 infection on interleukin-6 and D-dimer levels. Aids,29(11), 1355-1361.
Skhosana, L., Steegen, K., Bronze, M., Lukhwareni, A., Letsoalo, E., Papathanasopoulos, M. A. & Stevens, W. S. (2015). High prevalence of the K65R mutation in HIV-1 subtype C infected patients failing tenofovir-based first-line regimens in South Africa. PloS one, 10(2), e0118145.
2014
Killick, M., Capovilla, A., & Papathanasopoulos, M. A. (2014). Generation and Characterization of an HIV-1 Subtype C Transmitted and Early Founder Virus Consensus Sequence. AIDS research and human retroviruses, 30(10), 1001-1005.
Steegen, K., Levin, L., Ketseoglou, I., Bronze, M., Papathanasopoulos, M. A., Carmona, S., & Stevens, W. (2014). High-level cross-resistance to didanosine observed in South African children failing an abacavir-or stavudine-based 1 st-Line regimen. PloS one, 9(5), e97067.
Cerutti, N., Killick, M., Jugnarain, V., Papathanasopoulos, M., & Capovilla, A. (2014). Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 (gp120), which impairs thioredoxin-driven CD4 dimerization. Journal of Biological Chemistry, 289(15), 10455-10465.
Ketseoglou, I., Lukhwareni, A., Steegen, K., Carmona, S., Stevens, W. S., & Papathanasopoulos, M. A. (2014). Viral tropism and antiretroviral drug resistance in HIV-1 subtype C-infected patients failing highly active antiretroviral therapy in Johannesburg, South Africa. AIDS research and human retroviruses, 30(3), 289-293.
2012
Bronze, M., Steegen, K., Wallis, C. L., De Wolf, H., Papathanasopoulos, M. A., Van Houtte, M. & ART-A Consortium. (2012). HIV-1 phenotypic reverse transcriptase inhibitor drug resistance test interpretation is not dependent on the subtype of the virus backbone. PloS one, 7(4), e34708.
Mphahlele, M., Papathanasopoulos, M., Cinellu, M. A., Coyanis, M., Mosebi, S., Traut, T. & Hewer, R. (2012). Modification of HIV-1 reverse transcriptase and integrase activity by gold (III) complexes in direct biochemical assays. Bioorganic & medicinal chemistry, 20(1), 401-407.
Wallis, C. L., Papathanasopolous, M. A., Fox, M., Conradie, F., Ive, P., Orrell, C. & Stevens, W. (2012). Low rates of nucleoside reverse transcriptase inhibitor (NRTI) resistance detected in a well monitored cohort in South Africa accessing antiretroviral therapy. Antiviral therapy, 17(2), 313.
2011
Price, M. A., Wallis, C. L., Lakhi, S., Karita, E., Kamali, A., Anzala, O. & Kaleebu, P. (2011). Transmitted HIV type 1 drug resistance among individuals with recent HIV infection in East and Southern Africa. AIDS research and human retroviruses, 27(1), 5-12.
2010
Wallis, C. L., Venter, W. D., Stevens, W. S., & Papathanasopoulos, M. A. (2010). Case report of the rare deletion at codon 69 of reverse transcriptase in a South African HIV-1 subtype C infected patient. Virus genes, 41(3), 358-360.
Cerutti, N., Mendelow, B. V., Napier, G. B., Papathanasopoulos, M. A., Killick, M., Khati, M. & Capovilla, A. (2010). Stabilization of HIV-1 gp120-CD4 receptor complex through targeted interchain disulfide exchange. Journal of Biological Chemistry, 285(33), 25743-25752.