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The discipline of Radiation Oncology is a field of medicine which is concerned with the treatment of cancer using ionizing radiation.

The Johannesburg Hospital department of Radiation Oncology is one of the largest in the country. It is chaired by Dr Duvern Ramiah who heads a staff of consultant radiation oncologists, registrars specialising in radiation oncology, radiotherapists, oncology nurses and support staff. The division of medical physics provides invaluable support to the division in the delivery of high quality and accurate treatment.

The mission of the division is to provide expert and compassionate care in the treatment of all patients with cancer who are referred for radiation therapy. In order to achieve this goal, a multidisciplinary approach which includes the involvement of oncology surgeons, gynaecologists, medical oncologists and allied medical disciplines such as physiotherapists, speech therapists, and social workers is essential. A number of multidisciplinary clinics are well established including a head and neck clinic, gynaecology clinic, breast clinic, sarcoma clinic and skin clinic. The division is committed to the holistic care of the patient with cancer.

In addition, the division is involved in both postgraduate and to a lesser degree undergraduate training. Registrars in the division are exposed to a wide variety of cancers and receive training in all the modern techniques of radiation therapy delivery and in basic cancer chemotherapy.

A new department has been built at Johannesburg Hospital and all treatment and consultations are done at that venue. Doctors' offices and outpatient clinics are at Johannesburg Hospital area 348.